Rosetted Glioneuroma (RG) is a relatively new name for a type of primary brain tumor, hence not too many cases have been reported.  RG features distinct neurocytic rosettes and a glioma (similar to pilocytic astrocytoma).  Our family member was previously diagnosed with Juvenile Pilocytic Astrocytoma, but it has recently been renamed Rosetted Glioneuroma.  Overexpression and/or mutation of p53 and epidermal growth factor receptor have been related to low-grade and high-grade astrocytomas. 

BioJENC is interested in developing antibodies and/or inhibitors with specificities for these altered proteins.  Other proteins related to tumor growth and apoptosis are also included in our R&D.  Progress of our R&D will be posted as it becomes available, or contact us for specific information.  If you have information that may help expedite our study, please contact us.  Together, our wish to slow or stop the growth of brain tumors may come true. 

References:

Preusser M. et al.: Rosette-forming glioneuronal tumor of the fourth ventricle.  Acta Neuropathol (Berl). 2003 Nov; 106(5):506-8. Epub 2003 Aug 12.

Komori T. et al.: A rosette-forming glioneuronal tumor of the fourth ventricle: infratentorial form of dysembryoplastic neuroepithelial tumor? Am J Surg Pathol. 2002 May; 26(5):582-91.

Pollack IF, Finkelstein SD, Woods J, et al.: Expression of p53 and prognosis in children with malignant gliomas. N Engl J Med 346 (6): 420-7, 2002.

For more information on astrocytomas, visit www.cancer.gov